An aortic dissection is a serious condition caused by a tear between the innermost and middle layers of the aorta. As blood surges through the tear, it causes the inner and middle layers of the aorta to separate (dissect). Complicated aortic dissections include those that rupture or have malperfusion (abnormal perfusion of blood) to other organs. Biomechanical factors play a role in the development and propagation of aortic dissection. We are studying the disease using a multi-disciplinary approach combining mechanical characterisation, advanced 4D imaging, modelling and bioinformatics to develop patient-specific treatment strategies.