Immune Cell Migration Dynamics

Immune cell migration dynamics in response to chemokine concentration gradients

Immune cell migration dynamics in response to chemokine concentration gradients

All inflammatory processes require precise positioning and migration of immune cells to fight pathogens efficiently and be resolved once the pathogen threat is eliminated. Immune cells constantly follow trails of attractant molecules called chemokines to exchange information about antigens and trigger appropriate reactions. Little is known quantitatively about how extra-cellular chemokine distribution is controlled. We use numerical modelling and in-vitro microfluidic experiments in synergy to reproduce, isolate, and quantify the biophysical and biochemical phenomena known to affect it in-vivo. We aim to apply this to better understand inflammation and inflammatory diseases, including atherosclerosis.