Lymphatic Pumping Dynamics
A major function of the lymphatic vasculature is maintaining fluid homeostasis by returning interstitial fluid from all of the body’s tissues to the venous system. Lymphatic pumping is achieved by a combination…
Lymphatic Muscle Contraction Dynamics
Contraction of lymphatic muscle cells is crucial for propelling lymph through the body. These cells are a hybrid of cardiac, smooth and skeletal muscle types. Experimental evidence on whole cannulated vessels shows…
Cell Therapy Injection Strategies
Stem cells have shown promise for treatment of multiple diseases. Unfortunately, the techniques used to inject cells apply large forces to the cells that rupture their membranes, killing the cells. We are…
Aortic Dissection
An aortic dissection is a serious condition caused by a tear between the innermost and middle layers of the aorta. As blood surges through the tear, it causes the inner and middle…
Agent-Based Modelling
The lymphatic system maintains fluid balance throughout the body and is a crucial component of the immune system. Lymph nodes are stationed along the lymphatic network, sample the lymph and allow initiation…
Immune Cell Migration Dynamics
Immune cell migration dynamics in response to chemokine concentration gradients All inflammatory processes require precise positioning and migration of immune cells to fight pathogens efficiently and be resolved once the pathogen threat…
Device for Modulating Lymphatic Pumping
The current standard of care for lymphoedema is complex decongestive therapy (CDT), which is a combination of compression therapy, manual lymphatic drainage (MLD), exercise, and skin care. Using our validated computational models…
Lymph Node Implant
Around 1 in 5 breast cancer patients will develop lymphoedema in the arm after surgery involving removal of lymph nodes. Lymphoedema is a chronic, incurable condition which causes localised swelling of tissue…